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Literature summary extracted from

  • Bagossi, P.; Cheng, Y.S.E.; Oroszlan, S.; Toezser, J.
    Comparison of the specificity of homo- and heterodimeric linked HIV-1 and HIV-2 proteinase dimers (1998), Protein Eng., 11, 439-445.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.23.47 crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398 Human immunodeficiency virus 2

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.23.47 0.099
-
 VLQNYPIVQ pH 5.6, 37°C Human immunodeficiency virus 2
3.4.23.47 0.172
-
 VSQNYPIVQ pH 5.6, 37°C Human immunodeficiency virus 2
3.4.23.47 0.203
-
 VSQLYPIVQ pH 5.6, 37°C Human immunodeficiency virus 2
3.4.23.47 0.223
-
 VSQNYPLVQ pH 5.6, 37°C Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.47 GAG precursor protein of HIV-2 + H2O Human immunodeficiency virus 2
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.47 Human immunodeficiency virus 2
-
 human immunodeficiency virus type 2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.47 GAG precursor protein of HIV-2 + H2O
-
 Human immunodeficiency virus 2 ?
-
 ?
3.4.23.47 VLQNYPIVQ + H2O oligopeptide substrate Human immunodeficiency virus 2 VLQNY + PIVQ
-
 ?
3.4.23.47 VSQLYPIVQ + H2O oligopeptide substrate Human immunodeficiency virus 2 VSQLY + PIVQ
-
 ?
3.4.23.47 VSQNYPIVQ + H2O oligopeptide substrate Human immunodeficiency virus 2 VSQNY + PIVQ
-
 ?
3.4.23.47 VSQNYPLVQ + H2O oligopeptide substrate Human immunodeficiency virus 2 VSQNY + PLVQ
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.47 dimer
-
 Human immunodeficiency virus 2

Synonyms

EC Number Synonyms Comment Organism
3.4.23.47 retroviral aspartic proteinase
-
 Human immunodeficiency virus 2

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.23.47 0.0000333
-
 VLQNYPIVQ pH 5.6, 37°C Human immunodeficiency virus 2
3.4.23.47 0.0011
-
 VSQLYPIVQ pH 5.6, 37°C Human immunodeficiency virus 2
3.4.23.47 0.00213
-
 VSQNYPIVQ pH 5.6, 37°C Human immunodeficiency virus 2
3.4.23.47 0.00303
-
 VSQNYPLVQ pH 5.6, 37°C Human immunodeficiency virus 2